We use mass spectrometry-based proteomics tools to identify the specific substrates of E3 enzymes which have a role in the DNA damage response. Misregulation of these E3 enzymes leads to the appearance of cancer. Furthermore, we employ cell biology, biochemistry, and molecular biology techniques to unravel the function that ubiquitin signaling has in the regulation of the activity of these ubiquitin target proteins.
About the González Prieto lab
We study the role of ubiquitin signaling in the regulation of DNA repair- and cancer-relevant E3 enzymes specific targets.
