We use mass spectrometry-based proteomics tools to identify the specific substrates of E3 enzymes which have a role in genome biology. Misregulation of these E3 enzymes leads to the appearance of cancer. Furthermore, we employ cell biology, biochemistry, and molecular biology techniques to unravel the function that ubiquitin signaling has in the regulation of the activity of these ubiquitin target proteins.
The González Prieto lab will continue its activity at the Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) in Sevilla, Spain.
For more information: https://www.cabimer.es/en/research-groups/genome-proteomics/
