About the González Prieto lab

We study the role of ubiquitin signaling in the regulation of DNA repair- and cancer-relevant E3 enzymes specific targets.

We use mass spectrometry-based proteomics tools to identify the specific substrates of E3 enzymes which have a role in the DNA damage response. Misregulation of these E3 enzymes leads to the appearance of cancer. Furthermore, we employ cell biology, biochemistry, and molecular biology techniques to unravel the function that ubiquitin signaling has in the regulation of the activity of these ubiquitin target proteins.

News

ERA-CVD JTC grant for Dr. Konda Babu Kurakula

October 14, 2019
CCB visits Jilin University, Xi’an Jiaotong University and Shanghai Tech University

October 14, 2019
Investigator initiated research grant and Research grant from Dutch Pulmonary Hypertension Association

October 2, 2019

Groups

Chemical Immunology

Studying the basis of the immune system, bacterial infections and anti-cancer drugs.
Ubiquitin system chemistry & dynamics

Profiling the Ubiquitin-Proteasome System
Small Ubiquitin-like Modifiers

Uncovering signal transduction by SUMO
Ubiquitin signaling in DNA repair and cancer

Studying DNA repair- and cancer-relevant E3 enzymes specific targets
Chemical Signaling

Cell-to-cell communication via secreted factors, transmembrane receptors and intracellular signal transducers
Cell Signaling

Understanding TGF-ß- and MAP kinase-AP-1 pathways
Cell Signaling Dynamics

A window of opportunity: visualizing metastasis
Oncogenic Signaling in Melanoma
Molecular tumour genetics

Molecular cytogenetics and functional characterization of bone and soft tissue tumours
Transcriptional Regulation
DNA Replication & Repair

Molecular mechanisms of high-fidelity DNA replication
Genome Editing

Developing and integrating gene delivery and gene editing systems
Functional Genomics

Profiling the non-coding genome
Light and electron microscopy for biomedical applications
BioNanoPatterning

Bionanotechnology to probe immune system activation
Virus Cell Interactions

From innate sensing to oncolysis
Circadian Clocks

Investigating sleep regulation and sleep function
Cardiovascular Cell Biology

Where data science, virus and stem-cell biology is used to understand disease and develop therapeutics.
Diabetes Research

Molecular mechanisms of Type 1 and Type 2 Diabetes
Near patient diagnostics

High sensitivity diagnostic tools

Collaborate with us

Looking for information on one of our topics, a new place to conduct your research or experienced research to join forces with? Feel free to contact us.!