I have a background in cellular and molecular Biology and during my Masters internship, which was performed here in LUMC in the laboratory of Prof.dr. MJ Goumans, I have explored the mechanism of a new compound for the treatment of pulmonary arterial hypertension (PAH). The compound was developed by the lab of Prof.dr. J.M.F.G. Aerts at Leiden institute of Chemistry and is likely to restore the disturbed function of PAH endothelial cells. During my PhD, I aim to understand the mechanism of action of this compound in relation to the hall marks of PAH, disturbed cell growth, apoptosis, inflammation and TGFβ/BMP signalling, making use of primary cells isolated from the lungs of PAH patients and experimental animal models for PAH.
As a master student, I studied Molecular and Cellular Biology at the Faculty of Sciences at University of Porto, Portugal. During that time, I had the opportunity of doing my internship at the department of Molecular and Cellular Biology under the supervision of Prof.dr. MJ Goumans and Dr. KB Kurakula. During my internship, I became interested in Pulmonary Arterial Hypertension (PAH) and the lack of cure to this rare and deadly disease. In the beginning of 2018 I started my PhD in the group of Prof.dr. Goumans where I continued with the project I started during my internship and aim to unravel new pathways involved in pulmonary vascular remodeling within the context of PAH.
Groups: Cardiovascular Cell Biology