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Understanding the molecular mechanisms behind breast cancer dormancy. Dormancy is the reversible ability of cancer cells to stop proliferating, which is strongly linked to cancer recurrence and patient death. We are trying to identify genes important for dormancy. I am currently performing qPCR, westernblotting, and cell culture for this project, and am involved in in vivo experiments with mice.
Unravelling the dynamic role of TGFbeta in melanoma liver metastases. TGFbeta plays a major role in cancer metastasis, however, the dynamic role of this signalling pathway during colonization of melanoma cells in the liver has not been addressed. We are using Intravital microscopy and fluorescent based imaging probes to study this process in vivo. I am currently using western blotting, cloning, qPCR and cell culture for this project, and am involved in in vivo experiments with mice.
I studied Life Science Research at the Hogeschool Rotterdam and did two internships at the LUMC. My first internship was at the department of Kidney Disease. During this internship I studied the regulation of renin release in the macula densa of the kidney by miRNA-132. My second internship was at the Human Genetics department where I studied the role of a specific bacteria on the plaque formation in arteries of mice that where on a ‘high fat diet’. After I finished school in june 2017 I had a temporary job at an IVF clinic in Leiderdorp. In the mean time I got my job as a technician at the Chemical Cell Biology department where my main subjects are understanding the molecular mechanisms behind breast cancer dormancy and unravelling the dynamic role of TGFbeta in melanoma liver metastases.