My research addresses the role of the circadian clock in health and disease. The circadian clock generates 24-h rhythms in numerous physiological and behavioural processes, which helps the body to anticipate predictable daily changes in light, temperature, and food intake. Part of my research is dedicated to finding ways to optimize drug treatments by taking advantage of these 24-h rhythms in physiological processes. I am also interested in the physiological consequences of circadian misalignment, which occurs, for example, in night shift work, when the timing of sleep and food intake has shifted relative to the internal circadian clock. As night shift work is associated with adverse health effects, such as an increased risk of diabetes, obesity, cardiovascular disorders, and certain types of cancer, it is essential to better understand the underlying physiological mechanisms. I am currently working on the characterisation of the transcriptomic and metabolomic changes that occur during circadian misalignment.
I completed my PhD in 2017 at the Leiden University Medical Center studying 24-hour rhythmicity in physiological processes that determine the pharmacokinetics and pharmacodynamics of drug treatments in order to optimize drug treatments depending on the time of day that they are administered. I subsequently worked as a postdoctoral fellow at McGill University in Montreal, Canada, funded by a personal fellowship from the FRQS. Here, I investigated the physiological consequences of circadian misalignment in order to better understand the molecular mechanisms that contribute to the negative health effects associated with night shift work. In 2019, I joined the Meijer lab as a postdoctoral fellow.
• Simulated night shift work induces circadian misalignment of the human peripheral blood mononuclear cell transcriptome.
Kervezee, L; Cuesta, M; Cermakian, N; Boivin, D.B.
Proc Natl Acad Sci U S A, 2018, 115: 5540-5545
• Metabolic and cardiovascular consequences of shift work: The role of circadian disruption and sleep disturbances.
Kervezee, L; Kosmadopoulos, A.; Boivin, D.B.
Eur J Neurosci. 2018. doi: 10.1111/ejn.14216.
• Levofloxacin-induced QTc prolongation depends on the time of drug administration.
Kervezee, L.; Gotta, V.; Stevens, J.; Birkhoff, W.; Kamerling, I.; Danhof, M.; Meijer, J. H.; Burggraaf, J.
CPT Pharmacometrics Syst Pharmacol, 2016, 5: 466-74.