Circular RNAs (circRNAs) are a class of covalently closed, single-stranded RNA molecules formed through back-splicing of precursor mRNA (pre-mRNA) transcripts. Whether they play a role in regulating TGF-b signaling is largely unknown. We identified circTGFBR2(3-6), a circRNA derived from TGF-β receptor 2 (TGFBR2) pre-mRNA, as a novel potentiator of TGF-β/SMAD signaling at the receptor level and highlight IGF2BP3 as a critical m6A reader that mediates circTGFBR2(3-6)-driven breast cancer cell plasticity.
Wang, Q., Tjokrodirijo, R.T.N., Mei, H. et al. circTGFBR2(3-6) acts as an assembly platform for RNA-binding protein IGF2BP3 and TGFBR1 mRNA to enhance breast cancer cell plasticity. Cell Death Differ (2025).
Want to know more, please check out: https://doi.org/10.1038/s41418-025-01597-2
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