E3-ligase RNF114 is able to specifically detect Ubiquitinated ADPribose and extend it with K11-Ub chains in response to DNA damage
In a multi-disciplinary collaborative effort between the van der Heden van Noort laboratory at the Dept. of Cell and Chemical Biology in the Leiden University Medical Center and the Ahel laboratory at University of Oxford researchers Max Kloet, Chatrin Chatrin and Rishov Mukhopadhyay and their teams prepared an ubiquitinated-ADPribose probe and identified a family of RNF E3-ligases to interact with it using proteomics.
