THESIS DEFENCE ANNEMIEKE DE JONG

March 28, 2025

Thesis Defence: April 16, 2025 01.00 PM

PhD student: Annemieke de Jong

Title: Shining light on Proteolysis by the Ubiquitin Proteasome System. Fluorescence-Based Activity Profiling of the Ubiquitin Proteasome System & Peptide Splicing by the Proteasome

Thesis Advisors: Prof. Dr. J.J.C. Neefjes & Prof. Dr. H. Ovaa

Co-thesis advisor: Dr. M.P.C. Mulder

Groups

Neefjes Lab / Chemical Immunology

Studying the basis of the immune system, bacterial infections and anti-cancer drugs.
Van der Heden & Mulder & Geurink labs / Chemical Biology and Drug Discovery

Profiling the Ubiquitin-Proteasome System
Vertegaal Lab / Small Ubiquitin-like Modifiers

Uncovering signal transduction by SUMO
ten Dijke lab / Chemical Signaling

Cell-to-cell communication via secreted factors, transmembrane receptors and intracellular signal transducers
Szuhai Lab / Molecular tumour genetics

Molecular cytogenetics and functional characterization of bone and soft tissue tumours
Baker lab / Transcriptional Regulation
Lamers Lab / DNA Replication & Repair

Molecular mechanisms of high-fidelity DNA replication
Goncalves & Mikkers Lab / Genome Editing

Developing and integrating gene delivery and gene editing systems
Pang Lab / Functional Genomics

Profiling the non-coding genome
Koster Lab / Electron microscopy research

Cryo Electron Tomography and Artificial Intelligence methods
Sharp Lab / BioNanoPatterning

Bionanotechnology to probe immune system activation
Hoeben Lab / Virus Cell Interactions

From innate sensing to oncolysis
Meijer Lab / Circadian Clocks

Investigating sleep regulation and sleep function
Goumans Lab / Cardiovascular Cell Biology

Where data science, virus and stem-cell biology is used to understand disease and develop therapeutics.
't Hart & Zaldumbide Lab / Diabetes Research

Molecular mechanisms of Type 1 and Type 2 Diabetes
Corstjens Lab / Near patient diagnostics

High sensitivity diagnostic tools
Barcena Lab / Cell and structural biology of RNA virus infection