THESIS DEFENCE MERLE ANNE VAN GELDER

April 28, 2025

Thesis Defence: May 21, 2025 01.00 PM

PHD student: Merle Anne van Gelder

Title: Understanding Anthracycline Action. Molecular Insights to Improve Cancer Therapy

Thesis Advisors: Prof. Dr. J.J.C. Neefjes & Prof. Dr. H.S. Overkleeft

Co-Thesis advisor: Dr. S.Y. van der Zanden

Groups

Neefjes Lab / Chemical Immunology

Studying the basis of the immune system, bacterial infections and anti-cancer drugs.
Van der Heden & Mulder & Geurink labs / Chemical Biology and Drug Discovery

Profiling the Ubiquitin-Proteasome System
Vertegaal Lab / Small Ubiquitin-like Modifiers

Uncovering signal transduction by SUMO
ten Dijke lab / Chemical Signaling

Cell-to-cell communication via secreted factors, transmembrane receptors and intracellular signal transducers
Szuhai Lab / Molecular tumour genetics

Molecular cytogenetics and functional characterization of bone and soft tissue tumours
Baker lab / Transcriptional Regulation
Lamers Lab / DNA Replication & Repair

Molecular mechanisms of high-fidelity DNA replication
Goncalves & Mikkers Lab / Genome Editing

Developing and integrating gene delivery and gene editing systems
Pang Lab / Functional Genomics

Profiling the non-coding genome
Koster Lab / Electron microscopy research

Cryo Electron Tomography and Artificial Intelligence methods
Sharp Lab / BioNanoPatterning

Bionanotechnology to probe immune system activation
Hoeben Lab / Virus Cell Interactions

From innate sensing to oncolysis
Meijer Lab / Circadian Clocks

Investigating sleep regulation and sleep function
Goumans Lab / Cardiovascular Cell Biology

Where data science, virus and stem-cell biology is used to understand disease and develop therapeutics.
't Hart & Zaldumbide Lab / Diabetes Research

Molecular mechanisms of Type 1 and Type 2 Diabetes
Corstjens Lab / Near patient diagnostics

High sensitivity diagnostic tools
Barcena Lab / Cell and structural biology of RNA virus infection