Beau Neep
Research
During my PhD in the PHEniX lab at the Amsterdam UMC, I focused on the endothelial transcription factor SOX17 and its function in vascular health and shear stress-related signaling in the context of pulmonary arterial hypertension. During my postdoc with Marie-José, I will expand on this project by focusing on fibrosis of the heart and signaling of its vessels with 3D Vessels-on-a-Chip.
Curriculum vitae
I obtained my Bachelor’s in Biomedical Sciences at the University of Amsterdam in 2019, where I did a 5-month internship in the group of Renée van Amerongen focused on WNT signaling and live-cell imaging. I developed a love for microscopy during this internship, and therefore decided to pursue a Master’s in Biomedical Sciences with a specialization in Cell Biology and Advanced Microscopy from 2019 to 2021. After more than 1.5 years of internships during a global pandemic at the group of Stephan Huveneers in the Amsterdam UMC and Martijn Gloerich at the UMC Utrecht, both focused on mechanobiology, I joined the PHEniX laboratory in the Amsterdam UMC under supervision of Jurjan Aman in November 2021. During my PhD project, I further developed my skills in microscopic imaging, mechanical stimulation of endothelial cells with shear stress, and cloning of lentiviral plasmids. I joined the Goumans lab immediately after my PhD contract finished, and I will keep performing experiments in both Leiden and Amsterdam to strengthen the collaboration between both groups.
Publications
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DLC1 promotes mechanotransductive feedback for YAP via RhoGAP-mediated focal adhesion turnover
Hooglugt A, van der Stoel MM, Shapeti A, Neep BF, de Haan A, van Oosterwyck H, Boon RA, Huveneers S
J Cell Sci. 2024 Apr 15;137(8):jcs261687. doi: 10.1242/jcs.261687. Epub 2024 Apr 30. PMID: 38563084; PMCID: PMC11112125.
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BMP9 Modulates IL-33 Signaling to Mitigate EndMT in Pulmonary Arterial Hypertension. Hypertension. 2026
10.1242/jcs.261687. Epub 2024 Apr 30. PMID: 38563084; PMCID: PMC11112125. Becher C, Groeneveld EJ, Quarck R, Neep B, Pan X, Szulcek R, Tu L, Guignabert C, Bogaard HJ, Yu PB, de Man F, Sanchez-Duffhues G, Goumans MJ
doi: 10.1161/HYPERTENSIONAHA.125.24916. Epub 2026 Jan 21. PMID: 41564150; PMCID: PMC12822782
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Ameliorates Experimental Pulmonary Vascular Remodeling, but May Not Benefit Patients With Pulmonary Arterial Hypertension
Yoshida K, Toth E, Duijvelaar E, Neep B, Agarwal S, Pan X, Sanada T, Yoshida Y, Aman J, de Jesus Perez VA, Handoko ML, de Man FS, Sun XQ, Bogaard HJ. Empagliflozin
J Am Heart Assoc. 2026 Aug 4;15(15):e047945. doi: 10.1161/JAHA.125.047945. Epub 2026 Jul 25. PMID: 42500881.
