Sheila Caño Carrillo
Research
My research focuses on the molecular mechanisms underlying cardiac regeneration and tissue remodelling, with a particular interest in the regulatory functions of non-coding RNAs. During my doctoral research, I investigated the contribution of non-coding RNAs to cardiac development and regenerative processes, combining molecular and cellular biology approaches with transcriptomic and functional analyses.
Currently, my research focuses on epicardial biology and its role in cardiac regeneration and tissue remodelling. In particular, I study the cellular and molecular processes that regulate epicardial activation, migration and communication with the underlying myocardium, as well as the role of non-coding RNAs in these processes and their contribution to cardiac repair and regeneration.
CV
I obtained my Degree in Biology from the University of Jaén in 2020 and subsequently completed a Master's Degree in Biomedicine and Biotechnology. During my Master's, I was awarded a Collaboration Scholarship, which allowed me to begin my research career in cellular and molecular biology. In 2026, I completed a PhD in Molecular and Cellular Biology supported by an FPU fellowship, developing expertise in advanced molecular biology techniques, transcriptomics and the functional analysis of non-coding RNAs. As part of my doctoral training, I also completed a three-month predoctoral research stay at Stockholm University (The Wenner-Gren Institute, Department of Molecular Biosciences). Following my PhD, I was awarded a postdoctoral fellowship from the Ramón-Areces Foundation, which currently supports my research in the Goumans Lab.
Publications
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lncRNA-protein interaction controls myocardial ion channel expression and epicardial EMT during heart development in mice
Caño-Carrillo S, Lozano-Velasco E, Franco D. Elektra-Qki and Alien-Wt1
Cell Mol Life Sci. 2026 Jul 7;83(1):356. doi: 10.1007/s00018-026-06322-x. PMID: 42412164; PMCID: PMC13631190.
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Multiple 4q25 risk variants impair calcium homeostasis and compromise left atrial function
Jiménez-Sábado V,Tarifa C,Vad OB,Casabella-Ramón S,Manzano-Reche G,Lozano-Velasco E,Aceituno C,Caño-Carrillo S,Domínguez JN,Paludan-Müller C,Andreasen L,Montiel J,Guerra JM,Franco D,Svendsen JH,Rodriguez-Font E,Ginel A,Olesen MS,Hove-Madsen L
Cardiovasc Res. 2026 Aug 14;122(11):1455-1469. doi: 10.1093/cvr/cvag122. PMID: 42213894; PMCID: PMC13473974.
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Mef2c- and Nkx2-5-Divergent Transcriptional Regulation of Chick WT1_76127 and Mouse Gm14014 lncRNAs and Their Implication in Epicardial Cell Migration
Caño-Carrillo S, Garcia-Padilla C, Aranega AE, Lozano-Velasco E, Franco D
Int J Mol Sci. 2024 Nov 30;25(23):12904. doi: 10.3390/ijms252312904. PMID: 39684625; PMCID: PMC11640978.
