I’m last year PhD student in the group of Dr. David Baker in Department of Cell and Chemical Biology in LUMC. My study mainly focus on Angiogenesis which is the formation of blood vessels from the existing vasculature. Most of my research has been dedicated on studying the pathways that govern angiogenesis. DLL4/Notch signaling which is a fundamental pathway in angiogenesis is our main focus in the lab in the last four years. Furthermore, in collaboration with European lead factory a high throughput screen has been done to identify small molecules inhibitors of ETS transcription factor which potentially can be used as a target for anti-tumor therapy. To test these molecules, a number of complementary investigations were undertaken including molecular and biochemical assays, 3-D culture of primary human endothelial cells, metatarsal assays and in vivo study in zebrafish.
I completed my Master, studying and exploring zebrafish as a model organism for potential cancer therapeutic target, in Leiden University in the laboratory of Prof Herman Spaink, and Prof Ewa Snaar-Jagalska. I then moved to the Dr. Baker group as a Master student and continued as a PhD student working on angiogenesis which is a known hallmark of cancer. During my study I focus on exploring Dll4 signalling which is one of the principle pathways underlying blood vessel formation and dedicated my time to explore transcriptional and posttranscriptional regulation of Dll4. In addition being involve in discovery of novel anti-angiogenesis drug is one of highlighted part of my PhD period.
• Control of endothelial cell tube formation by Notch ligand intracellular domain interactions with activator protein 1 (AP-1)
Zary Forghany*, Francesca Robertson*, Alicia Lundby, Jesper V. Olsen, David A.Baker
J Biol Chem 2018 Jan 1;293(4):1229-1242
• Functional analyses of a human vascular tumor FOS variant identify a novel degradation mechanism and a link to tumorigenesis.
*David G.P van Ijzendoorn2 , *Zary Forghany1 , Frauke Liebelt1 , Alfred C. Vertegaal1 , Aart G. Jochemsen, Judith V.M.G Bovée2 , Karoly Szuhai1 , David A. Baker1
J Biol Chem 2017 292(52):21282-21290.
• Gene regulatory network model identification using artificial bee colony and swarm intelligence
Zary Forghany ; Mohsen Davarynejad ; B. Ewa Snaar-Jagalska
2012 IEEE Congress on Evolutionary Computation
Groups: Transcriptional Regulation