Disrupting Intracellular Protein-Protein Interaction to Inhibit Metastasis
In our recent paper we show that the interaction between Ena/VASP and WAVE2 plays a crucial role in coordinating lamellipodial protrusions and cell movement. The specific recognition motif involved in this interaction has a unique secondary structure, but has been very difficult to target with small molecules. We found that both genetic or pharmacological disruption of this interaction can effectively inhibit metastasis. Our research was performed in collaboration with University of Cologne and ProSION, and supported by Health~Holland, Top Sector Life Sciences & Health project ProMTAC TKI-LSH-DT2023-LUMC: 2024-02.
For more details, please read our paper: www.pnas.org/doi/10.1073/pnas.2423512122 with DOI number 10.1073/pnas.2423512122.
