LncRNA THAT ACTS AS MOLECULAR GLUE FOR TRANSCRIPTION FACTOR COMPLEXES AND PROMOTES CANCER CELL PLASTICITY
The cytokine TGF-β triggers cancer cells to become more migratory, invasive, and resistant to chemotherapy. We discovered that a TGF-β–induced long non-coding RNA (lncRNA) called LIMD1-AS1 enhances the SMAD protein response and cancer cell plasticity. LIMD1-AS1 stimulates the formation of a complex between the intracellular TGF-β effector SMAD3 and the transcriptional co-activator p300 by directly interacting with both factors.
