Jasper de Wolf

Research

As research technician in the Goumans group, I assist in multiple projects with a special focus on molecular based techniques and experiments. Applying these techniques I support research on TGF-β and BMP signaling. These growth factors and their transduction cascades are tightly regulated which is crucial for embryonic development and sustaining healthy physiology in adults. Deregulation of these signal transduction pathways might cause severe pathologies such as pulmonary arterial hypertension (PAH), Fibrodysplasia (FOP) or even heart failure. Understanding the molecular transduction pathway and regulation of TGF-β and BMP could provide new insights for new therapies.

Apart from this research, I am responsible for practical trainings for bachelor students. Using my laboratory experiences, I prepare reagents for and supervise these practical trainings, teaching a new generation of skilled researchers.

Curriculum Vitae

In 2024 I obtained my Bachelor’s degree (cum laude) at Avans University of Applied Science. During this study, I specialized in patient-oriented research. However, I always kept a strong interest in fundamental research. This brought me to Leiden University Medical Centre where I performed my graduation internship in its Immunology department (van der Veen group). There, I studied the molecular mechanism underlying the upregulation of a group of small non-coding RNAs upon distinct viral infections. Once I graduated, I started as a project-based research technician in de van der Veen group. These experiences at the immunology department deepened my expertise and affinity for molecular techniques. Since that project has ended, I joined the Goumans group at the CCB in 2026. Now I use my molecular expertise to support and assist in cardiovascular disease related research. In addition to my research responsibilities, I am also responsible for practical training for Bachelor students, preparing reagents and supervising during practical sessions.