Joyce Man
Research:
I am interested in the mechanisms of developmental gene regulation in mammals. Using model systems such as mouse embryonic stem cells, human induced pluripotent stem cells and their differentiated derivatives, I aim to understand what drives differential gene expression during development and which regulators establish cellular identity.
Curriculum Vitae:
I started my PhD in 2014 in the lab of Vincent Christoffels at Amsterdam UMC, where I genetically dissected the regulatory landscapes of key heart developmental genes, as well as the epigenetic control of tissue-specific regulatory element activity. For this, I combined molecular biology, developmental genetics and CRISPR/Cas9 engineering in mouse models. I then moved abroad for a postdoc at EMBL Heidelberg, followed by a year at the Francis Crick Institute in London, in the lab of Edith Heard. There, I investigated the regulatory principles of monoallelic expression, with a particular focus on X-chromosome inactivation and autosomal random monoallelic expression using molecular genetics, genomics and perturbation approaches in mouse embryonic stem cells. During my postdoc, I was awarded a joint EMBL–Stanford Bridging Excellence fellowship. I recently joined the lab of Joost Gribnau as a senior research scientist.
Publications
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Nppa and Nppb Deficiency Drives Ventricular Hypertrophy and Subendocardial Gene Deregulation in the Mouse Heart.
Giovou AE, Mulleners OJ, Günthel M, Man JCK, Jensen B, Gladka MM, Christoffels VM.
Int J Mol Sci. 2026 Mar 6;27(5):2450. doi: 10.3390/ijms27052450.
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Variant Intronic Enhancer Controls SCN10A-short Expression and Heart Conduction.
Man JCK, Bosada FM, Scholman KT, Offerhaus JA, Walsh R, van Duijvenboden K, van Eif VWW, Bezzina CR, Verkerk AO, Boukens BJ, Barnett P, Christoffels VM.
Circulation. 2021 Jul 20;144(3):229-242. doi: 10.1161/CIRCULATIONAHA.121.054083.
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Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart.
Man JCK, van Duijvenboden K, Krijger PHL, Hooijkaas IB, van der Made I, de Gier-de Vries C, Wakker V, Creemers EE, de Laat W, Boukens BJ, Christoffels VM.
Circ Res. 2021 Jan 8;128(1):115-129. doi: 10.1161/CIRCRESAHA.120.317045.
