Ubiquitin carboxy-terminal hydrolase L1 (UCHL1), also known as neuron-specific protein PGP9.5 (PGP9.5) or Parkinson disease 5 (PARK5), is a deubiquitinating enzyme active in neurons that constitutes 1 to 2% of the total brain proteins. UCHL1 variants have been linked with neurodegenerative disorders Parkinson's and Alzheimer's disease. In addition, high levels of UCHL1 also correlate often with cancer and especially metastasis. The function of UCHL1 activity, and its role in cancer and neurodegenerative disease is poorly understood and few UCHL1-specific, high quality, activity tools are available. This chemical probe, including a negative control and fluorescent version are now freely accessible via EUbOPEN; an Innovative Medicines Initiative (IMI) funded project to enable and unlock biology in the open.
Link to chemical probe 8RK64
Link to original publication on 8RK64