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CD8+T CELL CONTRIBUTION TO THE EPITHELIAL BARRIER DAMAGE DURING INFLUENZA INFECTION

November 1, 2017

New insight on how CD8+T cells contribute to reduce the epithelial barrier integrity during influenza infection.

CD8+T CELL CONTRIBUTION TO THE EPITHELIAL BARRIER DAMAGE DURING INFLUENZA INFECTION

The results suggest that ameliorating the function of epithelial ion channels and pumps may help reduce immunopathology during severe influenza infections.

This is a collaborative study between the Erasmus Medical Center, the Leiden University Medical Center, the Leiden University, Johannes Gutenberg University, the National Institute of Allergy and Infectious Diseases, University of Giessen and Marburg Lung Centre, and the University of Queensland..

van de Sandt, C.E., Barcena, M., Koster, A.J., Kasper, J., Kirkpatrick, C.J., Scott, D.P., de Vries, R.D., Herold, S., Rimmelzwaan, G.F., Kuiken, T. and Short, K.R., "Human Cd8+ T Cells Damage Noninfected Epithelial Cells During Influenza Virus Infection in Vitro" (2017) Am J Respir Cell Mol Biol, 57, 5, 536-546.

DOI: 10.1165/rcmb.2016-0377OC.

Groups: Koster Lab / Electron microscopy research

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