EMBO paper Ten Dijke Group

March 30, 2023

The process of epithelial to mesenchymal transition (EMT) in cancer cells has been associated with increased ability to metastasize and therapy resistance. How epithelial cells retain their epithelial traits and prevent malignant transformation is not well understood.

Researchers of the Department of Cell and Chemical Biology at Leiden University Medical Center have discovered a Long non coding RNA (LncRNA) that acts a gatekeeper for epithelial state of normal and cancer cells and that inhibits TGF-beta-induced epithelial to mesenchymal transition of breast and lung cancer cells.

Link to paper: https://www.embopress.org/doi/full/10.15252/embj.2022112806

Link to video synopsis: https://youtu.be/IDD7rhGchfk

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Neefjes Lab / Chemical Immunology

Studying the basis of the immune system, bacterial infections and anti-cancer drugs.
Van der Heden & Mulder & Geurink labs / Chemical Biology and Drug Discovery

Profiling the Ubiquitin-Proteasome System
Vertegaal Lab / Small Ubiquitin-like Modifiers

Uncovering signal transduction by SUMO
ten Dijke lab / Chemical Signaling

Cell-to-cell communication via secreted factors, transmembrane receptors and intracellular signal transducers
Szuhai Lab / Molecular tumour genetics

Molecular cytogenetics and functional characterization of bone and soft tissue tumours
Baker lab / Transcriptional Regulation
Lamers Lab / DNA Replication & Repair

Molecular mechanisms of high-fidelity DNA replication
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Pang Lab / Functional Genomics

Profiling the non-coding genome
Koster Lab / Electron microscopy research

Cryo Electron Tomography and Artificial Intelligence methods
Sharp Lab / BioNanoPatterning

Bionanotechnology to probe immune system activation
Hoeben Lab / Virus Cell Interactions

From innate sensing to oncolysis
Meijer Lab / Circadian Clocks

Investigating sleep regulation and sleep function
Goumans Lab / Cardiovascular Cell Biology

Where data science, virus and stem-cell biology is used to understand disease and develop therapeutics.
't Hart & Zaldumbide Lab / Diabetes Research

Molecular mechanisms of Type 1 and Type 2 Diabetes
Corstjens Lab / Near patient diagnostics

High sensitivity diagnostic tools
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