The integration of electron microscopy data sets

The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context.

The integration of electron microscopy data sets

Here we report on the outcomes of a workshop organized by the European Molecular Biology Laboratory, European Bioinformatics Institute at  Wellcome Genome Campus in, UK during which we discussed how to integrate structural data from a range of public archives. Representatives of many electron microscopy world-wide were present.  The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures.

Patwardhan, A., Brandt, R., Butcher, S.J., Collinson, L., Gault, D., Grunewald, K., Hecksel, C., Huiskonen, J.T., Iudin, A., Jones, M.L., Korir, P.K., Koster, A.J., Lagerstedt, I., Lawson, C.L., Mastronarde, D., McCormick, M., Parkinson, H., Rosenthal, P.B., Saalfeld, S., Saibil, H.R., Sarntivijai, S., Solanes Valero, I., Subramaniam, S., Swedlow, J.R., Tudose, I., Winn, M. and Kleywegt, G.J., "Building Bridges between Cellular and Molecular Structural Biology" (2017) Elife, 6.

DOI: 10.7554/eLife.25835.


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