My aim within a PhD project is to identify new approaches for therapy of uveal melanoma. Uveal melanoma is the most common intraocular tumor in adults and is lethal when metastatic. I performed a screen of targeted drugs to selectively inhibit the pathways known to be deregulated in uveal melanoma and to identify synergistic combinations. In addition, I am trying to identify new therapeutic targets or UM patients with phosphor-proteomic and CRISPR-Cas9 screen approaches.
I studied chemistry and biochemistry at Lomonosov Moscow State University in Russia. My diploma thesis topic concerned selection and study of structure of DNA -aptamers. I continued my research in the area of DNA aptamers in the University of Groningen in 2015-2017. Main focus was on using aptamers as novel drug-targeting agents.
Since May 2017 I work in the group of AG Jochemsen on the Horizon2020 project UMCure.