Metastasis of tumors is regarded as the largest contributor to cancer-related deaths, but physiologically relevant tumor models for cancer cell metastasis research are still lacking. Two-dimensional (2D) monolayer cell culture (on a flat surface) is traditionally used as in vitro model to investigate tumor behavior, migration, and invasion. Unfortunately, this (2-D) monolayer culture does not replicate the complexity of tumor and extracellular microenvironment where invasive cancer cells reside in tumor tissues. Therefore, 3D multicellular systems formed by cancer cells are gaining importance in the field of cancer cell invasion research. The Boukany group (TU Delft) closely collaborated with Ten Dijke’s lab (LUMC) to develop a new Microbucket-Hydrogel (Mb-H) micro platform for cancer cell invasion.
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Link to the publication: https://onlinelibrary.wiley.com/doi/full/10.1002/smll.202107757