THESIS DEFENSE ESTHER DRONKERS

THESIS DEFENSE ESTHER DRONKERS

On February 2nd, 2023 Esther Dronkers is defending her thesis ‘Enhancing epicardial EMT to repair the heart’

Promotor: Prof.dr. M.J.T.H.Goumans

Co-promotor: dr. A.M.Smits

THESIS DEFENSE ESTHER DRONKERS

Since the adult heart has minimal capacity to repair itself, myocardial infarction often leads to pathological remodeling and ultimately to the development of fatal heart failure. Upon ischemic injury, the epicardium, the outer layer of the heart which is essential for cardiac development, becomes re-activated and displays reparative potential. In this process, epicardial epithelial-to-mesenchymal transition (epiMT) is an essential step. We hypothesize that the reparative capacity of the heart can be improved by enhancing the participation of the epicardium to cardiac repair, particularly by stimulating the occurrence of epiMT. Therefore, the aim of my thesis is to find ways to boost epiMT in the injured heart. In this thesis, we describe a cell culture model which allows us to study epiMT. Using this model, we identify novel epiMT regulators. Because EMT is also involved in pathological remodeling, application of an epiMT stimulator should be transient and local. Therefore, we describe a method to locally administer these factors to the injured mouse heart using a drug-releasing biomaterial.

Groups

Collaborate with us

Looking for information on one of our topics, a new place to conduct your research or experienced research to join forces with?  Feel free to contact us.!

Read more