We investigate specific newly discovered immune systems in bacteria and archaea, focusing on the molecular machines that underpin their antiviral activity. In particular, we study proteins with helicase, nuclease, and/or protease functions to understand how they detect, process, and neutralize invading genetic material. Using structural biology, biochemistry, bacteriophage infection assays, and single-molecule approaches, we dissect how these complexes achieve recognition, specificity, and regulation. These mechanistic insights not only expand our understanding of microbial biology but also establish a foundation for engineering defense systems as versatile molecular tools.
News
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Deciphering the Regulatory Landscape of Enhancer RNAs in Health and Disease
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Eenvoudige bloedtest voor vroege kankerdetectie - Dr. Agustin Enciso Martinez and Sherif Bayoumy
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Interview Joke Meijer met het Reformatorisch Dagblad Magazine “Winterslaap is zo gek nog niet”