Date: Tuesday June 24th 2020, at 10AM
Title: BMP signaling in breast cancer’
Thesis advisor: Prof.dr. Peter ten Dijke
Summary: The main aim of Jiang’s thesis was to reveal the anti-/pro-invasive metastatic role of BMP/TGFβ signaling in breast cancer and explore possible therapeutic interventions. He elucidated the possibility of manipulating BMP/TGFβ signaling to achieve inhibition of breast cancer metastasis, including boosting BMP signaling via blockade of the BMP antagonist Grem1 extracellularly or via stimulation of small-molecule compounds intracellularly, preventing TGFβ signaling to allow accumulation of pro-oncogenic stimuli. He and his colleagues also highlighted the importance of selecting appropriate cancer types when adopting dual inhibition of PD-L1 and TGFβ signaling.
Group: Chemical Signaling