Ciricular RNA drives cancer cell plasticity
Circular RNAs (circRNAs) are a class of covalently closed, single-stranded RNA molecules formed through back-splicing of precursor mRNA (pre-mRNA) transcripts. Whether they play a role in regulating TGF-b signaling is largely unknown. We identified circTGFBR2(3-6), a circRNA derived from TGF-β receptor 2 (TGFBR2) pre-mRNA, as a novel potentiator of TGF-β/SMAD signaling at the receptor level and highlight IGF2BP3 as a critical m6A reader that mediates circTGFBR2(3-6)-driven breast cancer cell plasticity.
