The CI (CCB) Lab has earned the LEAF (Laboratory Efficiency Assessment Framework) sustainability certification at the bronze level. This recognition confirms the strong way in which sustainability is embedded in daily laboratory practice.
In previous work, prof ten Dijke and coworkers described the helminth TGFβ mimic TGM, which activates TGFβ signaling specifically in regulatory T cells (Tregs) by engaging TGFB1, TGFBR2, and the CD44 co-receptor. In current research they focuse on helminth TGM6, a highly selective antagonist of the mammalian TGFβ pathway. Through convergent evolution, this parasite has developed a sophisticated mechanism to inhibit mammalian TGFβ signaling.
Looking for information on one of our topics, a new place to conduct your research or experienced research to join forces with? Feel free to contact us.!