PostDoctoral researcher
Would you like to be part of a funded, multidisciplinary research project aimed at understanding the crosstalk beteween Ubiquitination and ADP-ribosylation? Do you hold a PhD title and have expertise in biochemistry or chemical biology? Then this might be the perfect position for you!
About your role
We are looking for a postdoctoral researcher for a 24 month multidisciplinary research project funded by an ERC Consolidator Grant . The aim of the project is to unravel the interplay between two post-translational modification, ubiquitin and ADP-ribose, and their roles in cellular signalling. Bacterial effector enzymes can attach ADP-ribose to Ubiquitin and conversely Ubiquitin is found to be conjugated to ADP-ribose in DNA damage responses. Understanding how these hybrid PTMs are constructed, what message the convey and how this helps to regulate (patho)physiology are the underlying aims of your work.
In this project, we will apply our unique chemical Ubiquitin based reagents and assays as well as further develop more advanced methods to generate next generations of research tools. Mass spectrometry driven proteomics and biochemical validation of candidates will also be part of the discovery workflow. We will set out to adress fundamental questions on the identity of enzymes involved, protein-protein interactions affected by and molecular mechanisms in which these hybrid PTMs play a role.
About you
- You have recently obtained your PhD degree in biochemistry, structural biology or chemical biology;
- Furthermore, you have a keen interest in protein modifications and experience with immunoprecipitation and protein-protein interactions;
- Fluency in English, being proactive and performance-driven, having a structured and responsible approach, and possessing good communication and writing skills are all desirable qualifications;
- Lastly, you look forward to working in a multidisciplinary and international academic setting.
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For more information contact gvanderheden@lumc.nl
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Postdoctoral funding
We are always interested in supporting grant applications of talented prospective postdoctoral fellows with experience in organic synthesis, protein chemistry, conjugation methods, or a related topic. Please contact us if you consider applying for Marie Skłodowska-Curie, NWO-Veni, DAAD, or other suitable fellowships.
