My research is aimed at understanding the molecular mechanism of the Mycobacterium tuberculosis mutasome, a group of proteins that create mutations in the M. tuberculosis genome that lead to antibiotic drug resistance. For this I use biochemistry, single-molecule methods, and cryo-EM.
I performed my bachelor’s studies in Applied Chemistry at the New University of Lisbon. Next, I did my PhD studies in the lab of Pedro Pereira at the Institute of Biomedical Sciences Abel Salazar, Porto. Following this I moved to the lab of Dirk Slotboom in Groningen where I worked as an EMBO post-doctoral Fellow on the structural and biochemical characterization of the bacterial Vitamin B12 membrane transporter and solved its crystal structure. Since February 2018 I have been working as a postdoctoral researcher in the lab of Meindert Lamers.
Functional and structural characterization of an ECF-type ABC transporter for vitamin B12.
Santos JA, Rempel S, Mous ST, Pereira CT, Ter Beek J, de Gier JW, Guskov A, Slotboom DJ
Elife. 2018. doi: 10.7554/eLife.35828.
What a difference a cluster makes: The multifaceted roles of IscR in gene regulation and DNA recognition.
Santos JA, Pereira PJB & Macedo-¬Ribeiro S,
Biochimica. Biophysica Acta (BBA) ¬Proteins and Proteomics. 2015. doi: 10.1016/j.bbapap.2015.01.010.
The unique regulation of iron-sulfur cluster biogenesis in a Gram-positive bacterium
Santos JA, Alonso-García N, Macedo-Ribeiro S, Pereira PJ,
Proc Natl Acad Sci USA. 2014. doi: 10.1073/pnas.1322728111.
Groups: DNA Replication & Repair