Msc. Almira Henic

Research:

I obtained my Bachelor’s and Master’s degrees in Biomedical Science at Leiden University, where I am specialized in the Research track: ‘’Immunity, Infection, and Tolerance’’. Throughout my study I have worked in a variety of group abroad focusing on cancer research in combination with immunology. I am starting as a PhD student in the group of Baoxu Pang from November 2018 onwards. My PhD project aims to study the role of non-coding regulatory regions in the development of cancer as well as multiple drug resistance, by using novel systematic and genome-wide methods.  

Curriculum Vitae:

I started my Bachelor research at the pulmonology department of Prof. Dr. Pieter Hiemstra at the LUMC where we mainly focused on how the innate immune system works, e.g. antimicrobial peptides. During my Master I went abroad: my first Master junior research project of 9-months was at the vaccine-strategy laboratory of Prof. Dr. Martin Müller at the German Cancer Research Center in Heidelberg, Germany. Here I generated human papillomavirus both in mammalian cells as pseudovirions and in insect cells as virus like particles, aiding in the development of a new L2-based vaccine giving a broad protection against HPV. Afterwards, I did a 9-month internship in the immune regulation laboratory of Prof. Dr. Nicole Joller at the University of Zürich, Switzerland; where I improved the in vitro differentiation protocol of effector and Treg cells and gained insight into the specializing Treg cells in vitro.

Publications

  • Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke.

    Gimano D. Amatngalim, Jasmijn A Schrumpf, Almira Henic, Esther Dronkers, Renate M. Verhoosel, Soledad R. Ordonez, Henk P. Haagsman, Maria Fuentes, Sriram Sridhar, Jamil Aarbiou, Richard A.J. Janssen, Annemarie N. Lekkerkerker, Pieter S. Hiemstra.

    Journal of Innate Immunity (2017) Feb 8. doi: 10.1159/0004551934

  • Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome

    F. Ribezzo, I.A.M. Snoeren, S. Ziegler, J. Stoelben, P.A. Olofsen, Almira Henic, M.V. Ferreira, S. Chen, U.S.A. Stalmann, G. Buesche, R.M. Hoogenboezem, Rafael Kramann, U. Platzbecker, M.H.G.P. Raaijmakers, Benjamin L. Ebert & Rebekka K. Schneider

    Leukemia (2019) Jan 16. doi: 10.1038/s41375-018-0350-3

Groups

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