Sr. Research Technician
In my current work I focus on detection of a pathogen-specific biomarker (CAA) for diagnosis of Schistosoma infection; the disease caused by infection with this parasitic flatworm is Bilharzia. It affects over 200 million people worldwide in Africa, Asia and South-America. In collaboration with dept. Parasitology (dr. Govert van Dam), we developed a lateral flow (LF) test able to detect a single worm. This was recently applied at LUMC to monitor a controlled human infection study (dr. Meta Roestenberg, dept. Infectious Diseases). The test is applicable on blood and urine, and is based on quantitative LF, immunochromatography using a unique luminescent reporter (upconverting particles, UCP). It is needed to identify infection, assess drug efficiency and monitor transmission-top or elimination settings. Noticed by the major schistosomiasis health- and organisations and research alliances, the test has major attention. Besides being a reference laboratory, we produce >>10.000 tests per year which are used worldwide in international research collaborations.
Other projects that I’m involved in are detection of human biomarker signatures (mycobacterial induced cell-mediated and humoral responses) and trough level determination of immunotherapeutics.
In 2001 I’ve received my Bachelor degree in Medical Biology at the HLO faculty of Natural Science and Technology at the Hogeschool Utrecht. From 2001-2004 I’ve been employed at TNO Leiden in the Department of Prevention and Healthcare. In 2005 I started at LUMC as a lab technician in the dept. of Parasitology (research group dr. Govert van Dam) developing Lateral Flow tests for Schistosomiasis and Tuberculosis using carbon and colloid gold reporters. In 2007 I moved to my present position at CCB, in the department previously called Molecular Cell Biology (research group dr. ir. Paul Corstjens) where I continued this work using a novel highly sensitive reporter technology (UCP).
Orcid id: https://orcid.org/0000-0002-2096-4523
Groups: Near patient diagnostics