Dr. Román González Prieto

Research:

I am trained as an biologist, and my research career has provided me a very broad set of expertise that ranges from molecular biology, cell biology and biochemistry to fluid mechanics, chromatography and mass spectrometry-based proteomics and bio-informatics.

Every cell cycle, cells have to deal with DNA damage induced by both endogenous and exogenous sources. To overcome these damages in the DNA, cells bear a plethora of signaling pathways and repair mechanisms, namely, the DNA damage response, which function is very tightly regulated by different post-translational modifications. My research focuses on the study of the role of protein post translational modification by ubiquitin and ubiquitin-like modifiers in the regulation of the DNA damage response. Using mass spectrometry-based approaches, TULIP methodology enables me to identify ubiquitin ligase-specific targets, on which I perform subsequent functional analysis to determine the relevance that ubiquitin has in the regulation of these targets.

Furthermore, I am involved in many research collaborations in order to perform mass spectrometry analysis for different projects.

Curriculum Vitae:

I studied biology at the University of Seville, Seville, Spain. Directly after finishing my studies I joined a spin-off company from the school of engineering, Ingeniatrics Tecnologías, where I worked for almost two years in the development of microfluidic-based applications for biology/biomedical sciences. Afterwards, I decided to make a turn in my career and joined the research group of Dr. Félix Prado in the Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), Seville, Spain, where I did my PhD.  studying the cell cycle-mediated control of the repair of replicative DNA lesions by the Homologous Recombination machinery. After my PhD, in 2013, I joined Alfred Vertegaal’s  group to study SUMO signaling using mass-spectrometry approaches. In January 2018 I was awarded the KWF Young Investigator Grant by the Dutch Cancer Society, which has enabled me to start my own independent research line.

ORCID ID:

http://orcid.org/0000-0001-8997-2321

 

Publications

  • The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

    Kumar, R.; Gonzalez-Prieto, R.; Xiao, Z.; Verlaan-de Vries, M.; Vertegaal, A. C. O.

    Nat Commun 2017, 8, 1809.

  • SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites

    Gonzalez-Prieto, R.; Cuijpers, S. A. G.; Luijsterburg, M. S.; van Attikum, H.; Vertegaal, A. C. O..

    EMBO reports 2015, 16, 512-519.

  • Rad51 replication fork recruitment is required for DNA damage tolerance.

    Gonzalez-Prieto, R.; Munoz-Cabello, A. M.; Cabello-Lobato, M. J.; Prado, F.

    The EMBO journal 2013, 32, 1307-1321

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