PhD Student
MSc Febe Vermue
Research:
A striking effect of tau-pathology is the disruption of the compartments of the highly connected auto- and endo-lysosomal pathways. In healthy cells, these pathways are regulated by de-ubiquitinating enzymes (DUBs) that provide a regulatory switch by modulating ubiquitin signals. The main focus of my PhD research is the role of DUBs in tau-induced dysfunction of the neural auto- and endo-lysosomal system. I am investigating whether there are changes in neural DUB activity upon tau-aggregation and what the target proteins are of these DUBs with an altered activity. Aside from my main research project I am involved in diverse side projects. These include the development of 2D and 3D neural cell cultures derived from iPSCs and investigating the cellular effects of the H284D mutation in UBE2J1 ubiquitin-conjugating enzyme.
Curriculum Vitae:
In August 2023, I completed my Master’s degree in Biomolecular Sciences at the VU University in Amsterdam. During my degree I specialized myself in Biological Chemistry and Molecular Cell Biology. I had the opportunity to conduct two internships during this time. I performed my first internship in the Erasmus Medical Center, where I investigated the inter individual differences in glucocorticoid recepter sensitivity in an obese patient cohort through trans-activation and trans-repression target genes. I performed my second internship in the Netherlands Cancer Institute. The aim of this research was to investigate complex formation in the eukaryotic mismatch repair system. I studied MutLa-PCNA interactions on DNA.
Publications
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The validation of macroprolactin analysis by polyethylene glycol precipitation using Fujirebio Lumipulse.
Vermue FC, Heesen R, de Boer D, Bons J, van den Berg SAA.
Pract Lab Med. 2022 Jul 13;31:e00292. doi: 10.1016/j.plabm.2022.e00292. PMID: 35860390; PMCID: PMC9289733.
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LAM-1 from Lysobacter antibioticus: A potent zinc-dependent activity that inactivates β-lactam antibiotics.
Stroek R, Wilson L, Goracke W, Kang T, Vermue F, Krco S, Mendels Y, Douw A, Morris M, Knaven EG, Mitić N, Gutierrez MCR, Schenk EB, Clark A, Garcia D, Monteiro Pedroso M, Schenk G. L
J Inorg Biochem. 2022 Jan;226:111637. doi: 10.1016/j.jinorgbio.2021.111637. Epub 2021 Oct 24. PMID: 34749064.
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Validation of the Fujirebio Lumipulse G1200 aldosterone assay for measurements during adrenal venous sampling for primary hyperaldosteronism
Vermue FC, van den Berg SAA.
Clin Chem Lab Med. 2021 Apr 8;59(12):e442-e444. doi: 10.1515/cclm-2021-0102. PMID: 33827152.
