About the Sharp lab

We use a combination of DNA nanotechnology, synthetic biology, super-resolution light microscopy and high-resolution cryoEM to investigate immune system activation

We are using DNA to determine structure-function relationships between antigen nanopatterns and immune system activation, and developing methods to exploit this activation. We combine this with state-of-the-art phase-plate electron cryo-tomography to solve various structures of our immune system. We are also working to combine the burgeoning fields of super-resolution light microscopy with cryoEM to achieve high-accuracy localization of tagged proteins within samples prepared for cryoEM. This will allow us to perform structural biology on individual proteins within cells.

Collaborate with us

Looking for information on one of our topics, a new place to conduct your research or experienced research to join forces with?  Feel free to contact us.!

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