Viruses are intracellular parasites that hijack cellular pathways and resources in fascinating ways.  Positive-stranded RNA viruses like MERS-coronavirus take control of specific intracellular membranes and remodel them into specialized viral replication organelle structures that support the process of RNA synthesis, required to replicate the viral genome.

Virus replication

Understanding their structure at a molecular level and the host-virus interplay involved in their biogenesis and function can pave the way to the development of novel anti-viral strategies against these rapidly evolving viruses. We focus on the replication of nidoviruses (coronaviruses and arteriviruses) and picornaviruses. Our experimental approach combines classical electron microscopy techniques with advanced methods like (cryo)electron tomography,  3D-SEM, and correlative light and electron microscopy. 


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Looking for information on one of our topics, a new place to conduct your research or experienced research to join forces with?  Feel free to contact us.!

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