Virus replication
Understanding their structure at a molecular level and the host-virus interplay involved in their biogenesis and function can pave the way to the development of novel anti-viral strategies against these rapidly evolving viruses. We focus on the replication of nidoviruses (coronaviruses and arteriviruses) and picornaviruses. Our experimental approach combines classical electron microscopy techniques with advanced methods like (cryo)electron tomography, 3D-SEM, and correlative light and electron microscopy.
