In the last decade, the ER has been shown to regulate multiple endosomal processes, such as fission or fusion events, maturation and growth receptor signaling. In 2016, I started my PhD here to work on organization of the endosomal system by the ER, more specifically involving ubiquitinating enzymes. Currently, I work on a project where we focus on control of EGFR signaling by the ER. Next to this, I work on the effects of ER stress on endosomal trafficking. This work displays my interest in how different organelles communicate to affect each other’s function.
During my Infection & Immunology studies at the Utrecht University, I worked at the interface of cell biology and immunology, focusing on endosomal transport in immune cells and protein degradation and subsequent antigen presentation of insulin-derived peptides in the ER. For a year afterwards, I worked on at the UMC Utrecht to continue working on the role of ERAD in insulin antigen presentation. In 2016, I started working at the Neefjes group on how ubiquitinating enzymes in the ER control endosomal processes.
Extracellular vesicles and Viruses- are they close relatives?
Nolte ’t Hoen, E.; Cremer, T.; Gallo, R.C.; Margolis, L.B.
Proceedings of the National Academy of Science PNAS, 2016, 113, 9155-9161