My research focuses on host-pathogen interaction mechanisms. To understand these highly dynamic molecular and cellular processes, I combine different microscopy, cell culture, and chemical biology techniques. Currently, I study how Salmonella infection promotes colon tumor formation using CRISPR-edited human-derived colon organoids.
I was trained in cell biology, oncology, and microbiology at the Ecole Normale Supérieure (ENS) of Cachan (FR). As a master student, I spent a year in the lab of Pr. Sheetz at the Columbia University (New York, US) working on mechanobiology mechanism of rigidity sensing by motile cells. Back in France, I performed my PhD under the direction of Jost Enninga at the Institut Pasteur (Paris, FR). I investigated epithelial cell invasion and intracellular trafficking triggered by Salmonella Typhimurium. I have joined the team of Sjaak Neefjes since November 2018 as a postdoctoral fellow to study Salmonella promotion of colon cancer.
Dynamic growth and shrinkage of the Salmonella-Containing Vacuole determines the intracellular pathogen niche.
Stévenin V, Chang YY, Le Toquin Y, Duchateau M, Gianetto QG, Luk CH, Salles A, Sohst V, Matondo M, Reiling N, Enninga J.;
Cell Rep. 2019. doi: 10.1016/j.celrep.2019.11.049
The early entry of Salmonella in a distinct tight compartment revealed at high temporal and ultrastructural resolution.
Fredlund J*, Santos JC*, Stévenin V*, Weiner A, Rechav K, Mallet A, Krijnse-Locker J, Elbaum M, Enninga J;
Cell Microbiol. 2018. doi: 10.1111/cmi.12816
Identifying parameters of host cell vulnerability during Salmonella infection by quantitative image analysis and modeling.
Voznica J, Gardella C, Belotserkovsky I, Dufour A, Enninga J, Stévenin V.;
Infect Immun. 2018. doi: 10.1128/IAI.00644-17.