My research focuses on host-pathogen interaction mechanisms. To understand these highly dynamic molecular and cellular processes, I combine different microscopy, cell culture, and chemical biology techniques. Currently, I study how Salmonella infection promotes colon tumor formation using CRISPR-edited human-derived colon organoids.
I was trained in cell biology, oncology, and microbiology at the Ecole Normale Supérieure (ENS) of Cachan (FR). As a master student, I spent a year in the lab of Pr. Sheetz at the Columbia University (New York, US) working on mechanobiology mechanism of rigidity sensing by motile cells. Back in France, I performed my PhD under the direction of Jost Enninga at the Institut Pasteur (Paris, FR). I investigated epithelial cell invasion and intracellular trafficking triggered by Salmonella Typhimurium. I have joined the team of Sjaak Neefjes since November 2018 as a postdoctoral fellow to study Salmonella promotion of colon cancer.
The early entry of Salmonella in a distinct tight compartment revealed at high temporal and ultrastructural resolution.
Fredlund J*, Santos JC*, Stévenin V*, Weiner A, Rechav K, Mallet A, Krijnse-Locker J, Elbaum M, Enninga J;
Cell Microbiol. 2018. doi: 10.1111/cmi.12816
Identifying parameters of host cell vulnerability during Salmonella infection by quantitative image analysis and modeling.
Voznica J, Gardella C, Belotserkovsky I, Dufour A, Enninga J, Stévenin V.;
Infect Immun. 2018. doi: 10.1128/IAI.00644-17.
FHOD is needed for directed forces and adhesion maturation during cell spreading and migration.
Iskratsch T, Yu CH, Mathur A, Liu S, Stévenin V, Dwyer J, Hone J, Ehler E, Sheetz M.
Dev Cell. 2013. doi: 10.1016/j.devcel.2013.11.003.