Tom de Boer

Associate professor

Research:

Interaction of sleep and circadian rhythms. Sleep is regulated by circadian and homeostatic mechanisms. Both are known to influence sleep and related variables, like alertness and cognitive performance. Whether the two influence each other is less clear. By measuring sleep and circadian clock functioning under different conditions (sleep deprived, jet lagged) we haves shown that the amplitude of the circadian clock and its responsiveness to light is reduced when an animal is sleep deprived.

Sleep, circadian rhythms and aging. Sleep and circadian rhythms change in the course of aging. Recently, we showed that mice sleep more and deeper when they age. This is in contrast with humans who generally tend to sleep less and less deep in the course of aging. Currently we are finalizing a program that investigates the influence of different environmental conditions (light at night, exercise, diet) on sleep and circadian rhythms in the course of aging in mice.

Sleep mechanisms. By applying drugs and making use of knockout models we investigate how sleep and waking are regulated. Recently, we have performed experiments with caffeine and other agonists and antagonists of the adenosine receptor on wildtype and knockout mouse models to investigate the working mechanism of sleep induction by adenosine release in the brain.

Curriculum Vitae:

I studied biology at the University of Groningen, the Netherlands, and performed the work for my PhD thesis at the institute of Pharmacology and Toxicology at the University of Zürich, Switzerland. My work there focused on the relationship between sleep and hibernation. For this I received my PhD from the University of Groningen. After that I spent time as a post-doc at the department of Veterinary Medicine of the University of Pennsylvania in Philadelphia, USA, where I worked on rapid-eye movement sleep regulation. During a subsequent post-doc at the institute of Pharmacology and Toxicology at the University of Zürich I worked on different knockout mouse models (prion protein, cytokines, K+-channels) and sleep regulation. Subsequently I moved to Leiden as a postdoc in Prof J. H. Meijers group, where I started working on the relationship between circadian rhythms and sleep.

Since 2013 I am an associate professor in this group. In addition, at present I am Vice-president basic of the European Sleep Research Society, and I am an Associate editor of the Journal of Sleep Research and Editorial board member of Clocks and Sleep.

Publications

  • Sleep states alter neuronal activity of the suprachiasmatic nucleus.

    Deboer, T.; Vansteensel, M.J.; Detari, L.; Meijer, J.H.

    Nat. Neurosci., 2003, 10, 1086-1090. doi: 10.1038/nn1122.

  • The two process model of sleep regulation: a reappraisal.

    Borbely, A.A.; Daan, S.; Wirz-Justice, A.; Deboer T.

    J. Sleep. Res., 2016, 25, 131-143. Doi: 10.1111/jsr.12371.

  • How old is your brain? Slow-wave activity in NREM sleep as a marker of brain rejuvenation after long-term exercise in mice.

    Panagiotou, M.; Papagioannopoulos, K.; Rohling, J.H.T.; Meijer, J.H.; Deboer, T.

    Front. Aging Neurosci., 2018, 10: 233. doi: 10.3389/fnagi.2018.00233.

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