Dr. Baoxu Pang

I received my PhD with Cum Laude from the Netherlands Cancer Institute, defining a novel mode of action of a broadly used anti-cancer drug, doxorubicin, and its anthracycline members. I discovered that doxorubicin and other anthracycline members can also destabilize nucleosomes and evict histones from particular chromatin regions upon intercalating into the chromatin. As a result, the DNA damage response is attenuated and the epigenome of the cell is deregulated. After a brief period of post-doc training at the Netherlands Cancer Institute, I moved to the Department of Genetics, Stanford University in the US, where I developed unique genome-wide screen systems to study the function of the non-coding genome. In 2018 I started my research group at the Department of Cell and Chemical Biology. I was awarded the Antoni van Leeuwenhoek Prize from NKI-AvL, the Academic Excellence Award from China, the Gisela Thier Fellowship from LUMC, the Bas Mulder Award/Young lnvestigator Grant from Dutch Cancer Society (KWF), and the ERC Starting Grant from European Research Council.

CURRENT POSITIONS

2018 –             Assistant Professor, Department of Cell and Chemical Biology, LUMC

2019 –             Guest Professor, Norman Bethune Center, Jilin University, China

PREVIOUS POSITIONS

2014 – 2018    Post-doc fellow, Stanford University, USA

2013 – 2014    Post-doc fellow, The Netherlands Cancer Institute, the Netherlands

EDUCATION

2006 – 2013     Ph.D. (CUM LAUDE), The Netherlands Cancer Institute, the Netherlands

2004 – 2006     M.Sc. (CUM LAUDE), University of Amsterdam, the Netherlands

2000 – 2004     B.Sc., Jilin University, China

AWARDS AND FELLOWSHIPS

2020                 ERC Starting Grant, European Research Council

2018                 Bas Mulder Award/ Young Investigator Grant, Dutch Cancer Society

2018                 Gisela Thier Fellowship, Leiden University Medical Center

2013                 Antoni van Leeuwenhoek Prize, the Netherlands Cancer Institute

2011                 Academic Excellence Award, China Scholarship Council

Publications

  • Systematic identification of silencers in human cells.

    Pang B., Snyder MP.

    Nature Genetics. 2020, Feb24

  • Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin.

    Pang B.*, Qiao X.*, Janssen L., Velds A., Groothuis T., Kerkhoven R., Nieuwland M., Ovaa H., Rottenberg S., van Tellingen O., Janssen J., Huijgens P.,  Zwart W. and Neefjes J. 

    Nature Communications. 2013;4:1908 

  • Chemical profiling of the genome with anti-cancer drugs defines target specificities.

    Pang B.*†, de Jong J.*, Qiao X.*, Wessels L.F.A.†, Neefjes J.†.

    Nature Chemical Biology. 2015, 11, 472–480.

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