Gabriella joined the Sharp Lab in September 2021 as a Postdoctoral Researcher and Swiss National Foundation Fellow. The Sharp lab focuses on the understanding of the human innate immune system, and especially the complement cascade. The human complement cascade plays an essential role in immune defense against invading pathogens, as well as mediating clearance of cellular debris and apoptotic cells. During her postdoctoral research in the Sharp Lab, Gabriella used DNA nanotechnology to determine the structure-function relationship of how IgM antibodies nanopatterns activate C1 complex.
Gabriella studied Cell and Molecular Biology at the University of Cagliari, Italy. She performed her master’s thesis in the group of Dr. Dario Piano, in Plant Physiology and Photobiology. At that time, she mainly focused on the biochemical and biophysical characterization of membrane-associated vacuolar enzymes. In July 2021, Gabriella obtained her PhD at the ETH Zurich. Under the supervision of Dr. Roger Benoit and Prof. Gebhard Schertler, she worked on the development of protein engineering strategies for structural studies of difficult targets. In particular, she focused on enabling single particle analysis (SPA, cryo-EM) of G protein-coupled receptors.
Since November 2023 she joined the Lamers Lab located in the LUMC