Sudarshan Narasimha Murthy
Research and CV
I am currently a Postdoctoral Researcher here, working towards discovery of small molecule inhibitors against DnaE1 from Mycobacterium tuberculosis. I have a PhD from the University of Oulu, Oulu, Finland where I developed small molecule inhibitors for specific mono-PARPs. My work includes protein expression, purification, and characterization, as well as structure solution using Cryo- EM and X-ray crystallography. Prior to my PhD, I worked as a Project Assistant/Research Assistant at the Indian Institute of Science, Bengaluru, India where I conducted phylogeographic studies of an endemic frog genus from the Western Ghats. I also have experience as a Technical Trainee at Aurigene Discovery Technologies, Bengaluru, India where I was involved in conducting crystallization experiments, data collection, and structure solution. In addition to my research experience, I have also been involved in teaching lab courses for the bachelor degree program at University of Oulu and co-supervised a Master’s thesis .
Publications
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[1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes.
Murthy S, Nizi MG, Maksimainen MM, Massari S, Alaviuhkola J, Lippok BE, Vagaggini C, Sowa ST, Galera-Prat A, Ashok Y, Venkannagari H, Prunskaite-Hyyryläinen R, Dreassi E, Lüscher B, Korn P, Tabarrini O, Lehtiö L.
J Med Chem. 2023 Jan 4. doi: 10.1021/acs.jmedchem.2c01460.
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4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10.
Murthy S, Desantis J, Verheugd P, Maksimainen MM, Venkannagari H, Massari S, Ashok Y, Obaji E, Nkizinkinko Y, Lüscher B, Tabarrini O, Lehtiö L.
Eur J Med Chem. 2018 Aug 5;156:93-102. doi: 10.1016/j.ejmech.2018.06.047
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Small-Molecule Screening Assay for Mono-ADP-Ribosyltransferases.
Haikarainen T, Murthy S, Maksimainen MM, Lehtiö L.
Methods Mol Biol. 2018;1813:237-244. doi: 10.1007/978-1-4939-8588-3_16.
