About the Mikkers lab

Pluripotent stem cells are superb for studying early development and for modeling of genetic disorders. In addition, they hold great promise for cell therapy purposes. We utilize our differentiation, genome editing and (induced) pluripotent stem cell knowledge to study the therapeutic potential of iPSCs and to model monogenic and complex genetic disorders.

PhD theses from lab alumni:

Tobias Messemaker “Exploring the world of non-coding genes in stem cells and autoimmunity https://openaccess.leidenuniv.nl/handle/1887/61075

News

Actively listening makes a difference but can be harder than removing a tumor.

April 18, 2024
Thesis defense Elma Mons

April 3, 2024
Invitation symposium prior to the inaugural lecture Marike Broekman

April 2, 2024

Groups

Neefjes Lab / Chemical Immunology

Studying the basis of the immune system, bacterial infections and anti-cancer drugs.
Van der Heden & Mulder & Geurink labs / Chemical Biology and Drug Discovery

Profiling the Ubiquitin-Proteasome System
Vertegaal Lab / Small Ubiquitin-like Modifiers

Uncovering signal transduction by SUMO
ten Dijke lab / Chemical Signaling

Cell-to-cell communication via secreted factors, transmembrane receptors and intracellular signal transducers
Szuhai Lab / Molecular tumour genetics

Molecular cytogenetics and functional characterization of bone and soft tissue tumours
Baker lab / Transcriptional Regulation
Lamers Lab / DNA Replication & Repair

Molecular mechanisms of high-fidelity DNA replication
Goncalves & Mikkers Lab / Genome Editing

Developing and integrating gene delivery and gene editing systems
Pang Lab / Functional Genomics

Profiling the non-coding genome
Lamers Lab / Electron microscopy research
Sharp Lab / BioNanoPatterning

Bionanotechnology to probe immune system activation
Hoeben Lab / Virus Cell Interactions

From innate sensing to oncolysis
Meijer Lab / Circadian Clocks

Investigating sleep regulation and sleep function
Goumans Lab / Cardiovascular Cell Biology

Where data science, virus and stem-cell biology is used to understand disease and develop therapeutics.
't Hart & Zaldumbide Lab / Diabetes Research

Molecular mechanisms of Type 1 and Type 2 Diabetes
Corstjens Lab / Near patient diagnostics

High sensitivity diagnostic tools
Barcena Lab / Cell and structural biology of RNA virus infection

Collaborate with us

Looking for information on one of our topics, a new place to conduct your research or experienced research to join forces with? Feel free to contact us.!