PhD Xiaoling Wang



Genome editing based on programmable nucleases permits “rewriting” genomic sequences in living cells for creating gene knockouts, or, in the presence of exogenous DNA, gene knock-ins. RNA-programmable nickases by inducing single-stranded DNA breaks instead of double-stranded DNA breaks, are substantially less disruptive to the genome when compared to nucleases. My research aims at identifying efficient and precise genome editing strategies based on RNA-programmable nickases and viral vector systems; and studying the structural integrity (or lack thereof) of genomic sequences in cells exposed to these genome editing strategies.


From 2015 to 2017, I worked at BGI Genomics as a wet-lab technician and dry-lab data analyst on a non-invasive prenatal testing project based on next generation sequencing (NGS) technology. From 2017 to 2021, I did my M.Sc. study at the BGI Education Center, University of Chinese Academy of Sciences, during which I focused on identifying important transcription factors during the embryonic development of an Amphioxus species using NGS analyses of mRNA expression and chromosomal accessibility. After graduation, I worked at BGI Genomics, providing international clients with technical support for COVID-19 genome assembly projects based on amplicon sequencing. In February 2022, I started my Ph.D. programme supported by a CSC-LU scholarship (awarded in 2021) under the supervision of Dr. Manuel Gonçalves at the department of Cell and Chemical biology of the Leiden University Medical Center.


Collaborate with us

Looking for information on one of our topics, a new place to conduct your research or experienced research to join forces with?  Feel free to contact us.!

Read more