Post-doc
PhD Virginie Stevenin
RESEARCH:
To survive and replicate within a cell, intracellular bacteria, viruses, or parasites, must accommodate the intracellular environment to fulfill their needs. In response to this invasion, the host cell initiates defense mechanisms to eliminate the pathogen. My research focuses on these highly dynamic interactions between intracellular pathogens and their host cells. Currently, I am investigating how the Gram-negative bacteria Salmonella uses mono-ubiquitination signals to control host small GTPases and establish its intracellular niche. I work in tight collaborations with Dr. Sapmaz, Dr. Berlin, and the light microscopy department.
For more info on my research, check my website!
CURRICULUM VITAE:
I was trained in cell biology, oncology, and microbiology at the Ecole Normale Supérieure (ENS) of Paris-Saclay (FR). In 2013, I spent a year in the lab of Pr. Sheetz at Columbia University (New York, US) working on mechanobiology. There I studied mechanisms of rigidity sensing by motile cells. Back in France, I performed my Ph.D. under the direction of Jost Enninga at the Institut Pasteur (Paris, FR). I investigated host cell targeting and host membrane remodeling during Salmonella infection of epithelial cells. I obtained my Ph.D. in October 2018 and started as a post-doc in the Neefjes lab in November 2018. Here, I combined my knowledge of intracellular bacteria pathogenesis with the lab’s expertise in endosome biology and ubiquitin enzymology. In June 2020, I diversified my skills by becoming a mother.
Publications
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Purification of infection-associated macropinosomes by magnetic isolation for proteomic characterization.
Stévenin V, Giai Gianetto Q, Duchateau M, Matondo M, Enninga J, Chang YY.
Nature Protocols. 2021 doi: 10.1038/s41596-021-00610-5.
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Dynamic growth and shrinkage of the Salmonella-Containing Vacuole determines the intracellular pathogen niche.
Stévenin V, Chang YY, Le Toquin Y, Duchateau M, Gianetto QG, Luk CH, Salles A, Sohst V, Matondo M, Reiling N, Enninga J
Cell Reports. 2019. doi: 10.1016/j.celrep.2019.11.049
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Identifying parameters of host cell vulnerability during Salmonella infection by quantitative image analysis and modeling.
Voznica J, Gardella C, Belotserkovsky I, Dufour A, Enninga J, Stévenin V.;
Infect Immun. 2018. doi: 10.1128/IAI.00644-17.
