Msc. Dharjath Ahamed Shahul Hameed


I did my MSc in Biomolecular Sciences, specialized in cell biology. On joining the lab of Huib Ovaa, I was trained in the synthesis of Ubiquitin (Ub) proteins, short peptides and other simple unnatural aminoacids which were used in solid phase peptide synthesis. After my short spell of being a technician, working mainly on synthesis of diubiquitins (diUb), I started my PhD research on more challenging aspects of Ub chemistry. My research spans the areas of development of ubiquitin conjugates including ubiquitin-peptide conjugates and diubiquitins; isotopic-labeled diUb molecules; synthetic cell-permeable Ub conjugates and Ub-based probes for all class of deubiquitinases. In addition, I also work on the development of peptide-based inhibitors for deubiquitinases. My expertise is the combination of peptide synthesis and its application in cell biology, which facilitates a better understanding of ubiquitin biology.

Curriculum Vitae:

I did my B.Tech in Industrial Biotechnology from Anna University, India. After graduating as MSc in Biomolecular Sciences from Vrije University in 2010, I started working as a technician in the lab of Huib Ovaa at the Netherlands Cancer Institute, Amsterdam. I then continued my research as a PhD graduate student, specializing in peptide synthesis and development of probes and assay reagents. My thesis will be about how Ub chemistry helps to better understand the biology of Ub.


  • How Chemical Synthesis of Ubiquitin Conjugates Helps To Understand Ubiquitin Signal Transduction.

    Hameed DS, Sapmaz A, Ovaa H.

    Bioconjug Chem. 2017. DOI: 10.1021/acs.bioconjchem.6b00140

  • Enhanced Delivery of Synthetic Labelled Ubiquitin into Live Cells by Using Next-Generation Ub-TAT Conjugates.

    Hameed DS, Sapmaz A, Gjonaj L, Merkx R, Ovaa H.

    Chembiochem. 2018. DOI: 10.1002/cbic.201800649

  • Synthesis of atypical diubiquitin chains.

    Oualid FE, Hameed DS, Atmioui DE, Hilkmann H, Ovaa H.

    Methods Mol Biol. 2012. DOI: 10.1007/978-1-61779-474-2_42.


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