Senior Scientist
Associate professor J.A.F. (Hans) van Dam
Research:
As a trained biochemist and molecular cell biologist I try to understand the role of (and the interplay between) gene-specific transcription factors and their regulators, such as signaling cascades and (de)ubiquitination enzymes. I have focused amongst others on AP-1, MAPK and TGFbeta family signaling components, and interacting pathways, such as WNT and DNA damage-induced pathways. I try to understand the mechanisms by which these signaling pathways are (de)regulated in tumor-specific settings, and to investigate how pro-oncogenic functions can be counteracted by specific drugs.
Curriculum Vitae:
I studied molecular sciences in Wageningen, the Netherlands. My PhD research has been performed in the group of Alex van der Eb at the laboratory of Molecular Carcinogenesis, University of Leiden, and focused on the mechanism of oncogenic transformation by the adenovirus E1A oncogene. I subsequently worked for 2 years as an EMBO fellow in the group of Peter Herrlich and Peter Angel at the Karlsruhe Research Center, and for 5 years as a KNAW fellow at the department of Molecular Cell Biology at the LUMC. I studied the mechanisms by which genotoxic stresses and growth factors can activate MAPkinase pathways and transcription factor AP-1 components, and, in addition, the effects of the various members and specific dimeric combinations of these protein families on cellular phenotypes.
Groups:
