SUMO signal transduction has been my main research topic since the last five years. I perform biochemistry, molecular biology and cell biology experiments. I frequently assist PhD students and postdoctoral fellows in the group with their projects and help running the lab.
I studied biochemistry at the Van Leeuwenhoek Institute in Delft and started working at the Rijks Instituut voor Volksgezondheid en Milieu (RIVM) in Leidschendam. Subsequently, I moved to Leiden to join the group of Alex J. van der Eb. First, I worked for Hans Bos on mutations in Ras oncogenes and later also for Alt Zantema and AG Jochemsen. Since five years, I am working in the SUMO signalling group of Alfred Vertegaal. I am experienced in biochemistry, molecular biology and cell biology.
The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.
Kumar, R.; Gonzalez-Prieto, R.; Xiao, Z.; Verlaan-de Vries, M.; Vertegaal, A. C. O.
Nat Commun 2017, 8, 1809.
Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein.
Schimmel J, Eifler K, Sigurðsson JO, Cuijpers SA, Hendriks IA, Verlaan-de Vries M, Kelstrup CD, Francavilla C, Medema RH, Olsen JV, Vertegaal AC.
Mol Cell. 2014 Mar 20;53(6):1053-66.
Uncovering global SUMOylation signaling networks in a site-specific manner.
Hendriks IA, D'Souza RC, Yang B, Verlaan-de Vries M, Mann M, Vertegaal AC.
Nat Struct Mol Biol. 2014 Oct;21(10):927-36.