Conjugation of SUMO to protein substrates in a dynamic and reversible manner is an efficient system to regulate their functional properties. SUMOylation influences numerous aspects of cellular machineries, including transcription, DNA damage repair, cell-cycle progression, apoptosis and thereby cellular homeostasis. Histones whose functions are orchestrated by coordinated patterns of various Post-Translational Modifications (PTMs) have been unearthed as substrates of SUMOylation. Aberration of histone PTMs leads to abnormal gene expression and uncontrolled cell proliferation, potentially leading to the development of cancer. Nevertheless, implication of SUMOylation on histones during cell cycle and cancer progression are still unexplored.
I completed my Masters as a biotechnology gold medalist from Rani Durgavati university, Jabalpur, India. Later I persued my PhD in cancer cell biology and biochemistry from Advance Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Mumbai, India. My research was focused on deciphering the role of Keratin 8 and it’s phosphorylation in neoplastic progression of squamous cell carcinoma together with the underlying mechanism involved. Recently I have joined LUMC through LEaDIng Fellowship program as a post-doctoral fellow to continue my research career.
Depletion of Keratin 8/18 modulates oncogenic potential of A431 cells by governing multiple signaling pathways.
Tiwari Richa, Sahu Indrajit, Soni Biharilal, Sathe Gajanan.J, Thapa Pankaj, Patel Pavan, Sinha Shruti, Vadivel Chillakrishna, Patel Sweta, Oak Swapnil, Thorat Rahul, Gowda Harsha, and Vaidya Milind M.
FEBS J 2018, 285: 1251-1276. doi:10.1111/febs.14401
• Quantitative phosphoproteomic analysis reveals system‐wide signaling pathways regulated by site‐specific phosphorylation of Keratin‐8 in skin squamous cell carcinoma derived cell line.
Tiwari Richa, Sahu Indrajit, Soni Biharilal, Sathe Gajanan.J, Datta Keshava, Thapa Pankaj, Sinha Shruti, Vadivel Chillakrishna, Dhaka Bharti , Gowda Harsha, and Vaidya Milind M.,
Proteomics 2017, 17, 1600254. doi:10.1002/pmic.201600254