Chao Li
Research:
The tumor microenvironment (TME) plays an important role in cancer development. It consists of a large number of cell types, such as fibroblasts and immune cells embedded in extracellular matrix. Cancer associated-fibroblasts (CAFs) are the most abundant cell type in TME, which not only provide physical support for tumor cells but also generate a great number of immunosuppressive molecules. Notably, exosomes are an important way for CAFs to communicate with other cell types in the TME. We are interested in how CAFs-derived exosomes modulate the TME and regulate the caner development. We aim to identify specific molecules in CAF-derived exosomes that exert important regulatory functions in this process. Our studies will be focused on triple negative breast cancer.
Curriculum Vitae:
I got my master’s degree and bachelor’s degree at Wuhan University and Jilin University, respectively. My former research was mainly performed in College of Life Sciences at Wuhan University, focusing on the function of Protein Tyrosine Phosphatases (PTPs) and Deubiquitinases (DUBs) on modulating signaling pathways in different cancers, such as colorectal cancer and bladder cancer. Now I’m performing research as a PhD in Cell and Chemical Biology department of LUMC under the supervision of Peter ten Dijke. Specifically, I will focus on the role of CAFs derived-exosomes in the development of TNBC.
Publications
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PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis.
Li C, Li SZ, Huang XC, Chen J, Liu WB, Zhang XD, Song XM, Du RL.
Genes & Diseases. 2020 Aug. In press.
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UCHL3 promotes ovarian cancer progression by stabilizing TRAF2 to activate the NF-κB pathway.
Zhang MH, Zhang HH, Du XH, Gao J, Li C, Shi HR, Li SZ.
Oncogene. 2020 Jan;39(2):322-333.
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Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response.
Li SZ, Shu QP, Song Y, Zhang HH, Liu Y, Jin BX, Liuyu TZ, Li C, Huang XC, Du RL, Song W, Zhong B, Zhang XD.
Nature communications. 2019 Jul 19;10(1):3233.
