Your position
Would you like to be part of a ZON-MW project as a postdoc on developing strategies to stop the metastasis of malignant cancer cells and make them therapy-sensitive again? Then don't hesitate to apply for this great postdoc position!
In short
• You will be part of our research group focused on studying signal transduction processes in human cells
• You will study the important role of TGF-beta in the epithelial to mesenchymal transition of cancer cells and investigate how we can use existing drugs to counteract the malignant behavior of mesenchymal cancer cells
• You have a PhD degree in cell biology/biochemistry or similar
What you do
Most cancer patients die from malignant metastases, or because they have become insensitive to chemotherapy. In this multidisciplinary project, which will be carried out in collaboration with ErasmusMC and TuDelft, we aim to repurpose existing drugs to selectively change the behavior of aggressive cancer cells to non-invasive and therapy-sensitive cancer cells or change them into benign fat cells. This will be accomplished by using a library of over 5685 chemical compounds/drugs. The initial results of the screenings look promising. You will use cell biology, biochemistry and in vivo cancer models. In collaboration with colleagues, you will also test the effect of selected compounds/drugs on circulating tumor cells from breast and lung cancer patients.
What we ask
We are looking for an enthusiastic, motivated and result driven postdoc. You have a PhD in cell biology/biochemistry or in a similar field. In addition, you have experience with molecular cell biology and studying signal transduction. It is an advantage if you have knowledge of zebrafish or mouse xenograft cancer models. You are creative and professional, and have excellent communication skills, both verbal and written.
Your workplace
The Department of Cell and Chemical Biology consists of multidisciplinary research groups and offers a motivating and friendly work environment where seminars and multidisciplinary meetings regularly take place. The Ten Dijke laboratory is interested in how cells communicate with each other, how miscommunication can lead to diseases, such as cancer, and how new mechanistic insights can be applied in new therapies.
Your career at the LUMC
The LUMC offers opportunities to maintain and develop your knowledge and skills. We offer internal courses and in-service training to help you with your personal development. We also offer services for mobility and career advice.
More information
Initially, we will offer you an employment contract for two years, with a possible extension to five years, the entire duration of the project.
For more information about the research group, please visit: https://ccb.lumc.nl/about-the-ten-dijke-lab-34
Giving a presentation may be part of the assessment. We may also ask for references, so please attach the names and contact information of three references.
Acquisition in response to this vacancy is not appreciated.
Position: Fulltime (36 hours per week)
Educational requirements; PhD
Closing date april 24th 2022
Salary: max €4615
Contact: Peter ten Dijke, professor, department of Cell and Chemical Biology
+31 (0)71 526 9271
p.ten_dijke@lumc.nl
