Chuannan Fan


Only 2% of human genome are protein coding genes and the remaining of them are considered as garbage. These years numerous studies uncovered lncRNAs, a class of non-coding RNAs that do not code proteins, act as key regulators in all kinds of psychological and pathological processes. However, the regulatory roles of lncRNAs in breast cancer progression are just emerging. Our aim is to apply methods including RNA sequencing, RNA immunoprecipitation and lncRNA knockout library based on Crispr-Cas9 to identify lncRNAs that play essential roles in the transduction of transforming growth factor (TGF)-b signalling pathway, epithelial to mesenchymal transition (EMT) and breast cancer progression.    

Curriculum Vitae:

I performed my master work at the State Key Laboratory of Cellular Stress Biology in Xiamen University, China. Work there focused on screening of microRNAs in tumor metastasis and studying how the matricellular proteins like periostin modulate the hepatic metastatic niche of colorectal cancer cells. Now I am a PhD student at Department of Cell and Chemical Biology in Leiden University Medical Center, the Netherlands. As a PhD student in the group of Dr. Peter ten Dijke, I am studying the functions of long non-coding RNAs (lncRNAs) in TGF-b signalling transduction and breast cancer progression.


  • Biphasic role of TGF-β in cancer pregression: from tumor suppressor to tumor promoter.

    C Fan*, J Zhang*, W Hua and P ten Dijke.

    Encyclopedia of Cancer (3rd Edition), 2017. (Review)

  • MicroRNA-543 suppresses colorectal cancer growth and metastasis by targeting KRAS, MTA1 and HMGA2.

    Fan C*, Lin Y*, Mao Y*, Huang Z*, Liu AY, Ma H, Yu D, Maitikabili A, Xiao H, Zhang C, Liu F, Luo Q, Ouyang G.

    Oncotarget. 2016. doi: 10.18632/oncotarget.7989.

  • MicroRNA-33b inhibits breast cancer metastasis by targeting HMGA2, SALL4 and Twist1.

    Lin Y*, Liu AY*, Fan C*, Zheng H, Li Y, Zhang C, Wu S, Yu D, Huang Z, Liu F, Luo Q, Yang CJ, Ouyang G.

    Sci Rep. 2015. doi: 10.1038/srep09995.


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