Postdoc

Only 2% of human genome are protein coding genes and the remaining of them are considered as garbage. These years numerous studies uncovered lncRNAs, a class of non-coding RNAs that do not code proteins, act as key regulators in all kinds of psychological and pathological processes. However, the regulatory roles of lncRNAs in breast cancer progression are just emerging. Our aim is to apply methods including RNA sequencing, RNA immunoprecipitation and lncRNA knockout library based on Crispr-Cas9 to identify lncRNAs that play essential roles in the transduction of transforming growth factor (TGF)-b signalling pathway, epithelial to mesenchymal transition (EMT) and breast cancer progression.
I performed my master work at the State Key Laboratory of Cellular Stress Biology in Xiamen University, China. Work there focused on screening of microRNAs in tumor metastasis and studying how the matricellular proteins like periostin modulate the hepatic metastatic niche of colorectal cancer cells. Now I am a PhD student at Department of Cell and Chemical Biology in Leiden University Medical Center, the Netherlands. As a PhD student in the group of Dr. Peter ten Dijke, I am studying the functions of long non-coding RNAs (lncRNAs) in TGF-b signalling transduction and breast cancer progression.
C Fan*, J Zhang*, W Hua and P ten Dijke.
Encyclopedia of Cancer (3rd Edition), 2017. (Review)
Fan C*, Lin Y*, Mao Y*, Huang Z*, Liu AY, Ma H, Yu D, Maitikabili A, Xiao H, Zhang C, Liu F, Luo Q, Ouyang G.
Oncotarget. 2016. doi: 10.18632/oncotarget.7989.
Lin Y*, Liu AY*, Fan C*, Zheng H, Li Y, Zhang C, Wu S, Yu D, Huang Z, Liu F, Luo Q, Yang CJ, Ouyang G.
Sci Rep. 2015. doi: 10.1038/srep09995.
Looking for information on one of our topics, a new place to conduct your research or experienced research to join forces with? Feel free to contact us.!